Synthesis and Kinetic Evaluation of Cyclophostin and Cyclipostins Phosphonate Analogs As Selective and Potent Inhibitors of Microbial Lipases-Reference-Cited by-同舟云学术

Synthesis and Kinetic Evaluation of Cyclophostin and Cyclipostins Phosphonate Analogs As Selective and Potent Inhibitors of Microbial Lipases

Published:2012-11-07 Issue:22 Volume:55 Page:10204-10219
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Point Vanessa¹,Malla Raj K.²,Diomande Sadia¹,Martin Benjamin P.²,Delorme Vincent¹,Carriere Frederic¹,Canaan Stephane¹,Rath Nigam P.²,Spilling Christopher D.²,Cavalier Jean−François¹

Affiliation:

1. CNRS - Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse, UMR 7282, 31 chemin Joseph Aiguier, 13402 Marseille cedex 20, France

2. Department of Chemistry and Biochemistry, University of Missouri—St. Louis, 1 University Boulevard, St. Louis, Missouri 63121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301216x

Reference61 articles.

1. Lipases: Interfacial Enzymes with Attractive Applications

2. The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase

3. Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers

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