1. Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, Centre for Ecology and Hydrology, Monks Wood, Abbots Ripton, Huntingdon PE28 2LS, and Cardiff School of Biosciences, Main Building, Cardiff University, Park Place, Cardiff CF10 3TL, Wales, United Kingdom