Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor-Reference-Cited by-同舟云学术

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor

Published:2008-07-12 Issue:15 Volume:51 Page:4632-4640
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harris Philip A.¹,Boloor Amogh¹,Cheung Mui¹,Kumar Rakesh¹,Crosby Renae M.¹,Davis-Ward Ronda G.¹,Epperly Andrea H.¹,Hinkle Kevin W.¹,Hunter Robert N.¹,Johnson Jennifer H.¹,Knick Victoria B.¹,Laudeman Christopher P.¹,Luttrell Deirdre K.¹,Mook Robert A.¹,Nolte Robert T.¹,Rudolph Sharon K.¹,Szewczyk Jerzy R.¹,Truesdale Anne T.¹,Veal James M.¹,Wang Liping¹,Stafford Jeffrey A.¹

Affiliation:

1. GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800566m

Reference22 articles.

1. Angiogenesis: an organizing principle for drug discovery?

2. A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis

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