C-Isoprenylation of Flavonoids Enhances Binding Affinity toward P-Glycoprotein and Modulation of Cancer Cell Chemoresistance-Reference-Cited by-同舟云学术

C-Isoprenylation of Flavonoids Enhances Binding Affinity toward P-Glycoprotein and Modulation of Cancer Cell Chemoresistance

Published:2001-01-26 Issue:5 Volume:44 Page:763-768
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Comte Gilles¹,Daskiewicz Jean-Baptiste¹,Bayet Christine¹,Conseil Gwenaëlle¹,Viornery-Vanier Armelle¹,Dumontet Charles¹,Di Pietro Attilio¹,Barron Denis¹

Affiliation:

1. Laboratoire des Produits Naturels, CNRS-UMR 5013, UFR de Chimie-Biochimie, Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France, Institut de Biologie et Chimie des Protéines, CNRS-UPR 412, 7 Passage du Vercors, 69367 Lyon Cedex 07, France, and Laboratoire de Cytologie Analytique, Faculté de Médecine Rockefeller, INSERM-U 453, 8 Avenue Rockefeller, 69880 Lyon, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm991128y

Reference22 articles.

1. BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

2. The biology of the P-glycoproteins

3. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

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