1. Chemistry Department, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada, Faculty of Pharmacy, Department of Pharmacology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada, and St.-Justine Hospital Research Centre, Université de Montréal, 3175 Côte-Ste-Catherine, Montreal, Quebec, H3T 1C5 Canada