Molecular Details of INH-C10 Binding to wt KatG and Its S315T Mutant

Author:

Teixeira Vitor H.1,Ventura Cristina12,Leitão Ruben13,Ràfols Clara4,Bosch Elisabeth4,Martins Filomena1,Machuqueiro Miguel1

Affiliation:

1. Centro de Química e Bioquímica and Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal

2. Instituto Superior de Educação e Ciências, Alameda das Linhas de Torres 179, 1750 Lisboa, Portugal

3. Área Departamental de Engenharia Química, Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, R. Conselheiro Emídio Navarro, 1, 1959-007 Lisboa, Portugal

4. Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain

Funder

Division of Chemistry

National Institute of Allergy and Infectious Diseases

Fundação para a Ciência e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference97 articles.

1. WHO. Global TuberculosisReport 2014. http://www.who.int/tb/publications/global_report/en/index.html(accessed Oct 27, 2014) .

2. New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development

3. New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future

4. Tuberculosis: The drug development pipeline at a glance

5. Working Group on New TB Drugs. Drug Pipeline. http://www.newtbdrugs.org/pipeline.php(accessed Jan 22, 2014) .

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