Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice-Reference-Cited by-同舟云学术

Identification of a Novel Pyrazolo[3,4-d]pyrimidine Able To Inhibit Cell Proliferation of a Human Osteogenic Sarcoma in Vitro and in a Xenograft Model in Mice

Published:2007-10-11 Issue:23 Volume:50 Page:5579-5588
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Manetti Fabrizio¹,Santucci Annalisa¹,Locatelli Giada A.¹,Maga Giovanni¹,Spreafico Adriano¹,Serchi Tommaso¹,Orlandini Maurizio¹,Bernardini Giulia¹,Caradonna Nicola P.¹,Spallarossa Andrea¹,Brullo Chiara¹,Schenone Silvia¹,Bruno Olga¹,Ranise Angelo¹,Bondavalli Francesco¹,Hoffmann Oskar¹,Bologna Mauro¹,Angelucci Adriano¹,Botta Maurizio¹

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via Alcide de Gasperi 2, I-53100 Siena, Italy; Dipartimento di Biologia Molecolare, Università degli Studi di Siena, via Fiorentina 1, I-53100 Siena, Italy; Istituto di Genetica Molecolare, IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy; Dipartimento di Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, Università degli Studi di Siena, I-53100 Siena, Italy; Siena Biotech, Via Fiorentina 1, I-53100 Siena, Italy;...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061449r

Reference27 articles.

1. Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation

2. Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT

3. Nongenotropic, Anti-Apoptotic Signaling of 1α,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes

4. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

5. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

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