Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

Author:

Chen Wentao1,Dong Jiajia1,Plate Lars1,Mortenson David E.1,Brighty Gabriel J.1,Li Suhua1,Liu Yu1,Galmozzi Andrea1,Lee Peter S.1,Hulce Jonathan J.1,Cravatt Benjamin F.1,Saez Enrique1,Powers Evan T.1,Wilson Ian A.1,Sharpless K. Barry1,Kelly Jeffery W.1

Affiliation:

1. Department of Chemistry and §Department of Molecular and Experimental Medicine, ∥Department of Chemical Physiology, ⊥Department of Integrative Structural and Computational Biology, #The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States

Funder

National Center for Research Resources

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Allergy and Infectious Diseases

Leukemia and Lymphoma Society

National Institute of General Medical Sciences

Skaggs Institute for Chemical Biology, Scripps Research Institute

Lita Annenberg Hazen Foundation

George W Hewitt Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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