Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes-Reference-Cited by-同舟云学术

Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes

Published:2016-09-14 Issue:38 Volume:138 Page:12527-12533
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Renata Hans¹,Lewis Russell D.¹,Sweredoski Michael J.¹,Moradian Annie¹,Hess Sonja¹,Wang Z. Jane¹,Arnold Frances H.¹

Affiliation:

1. Division of Chemistry and Chemical Engineering, MC 210-41, and ‡Proteome Exploration Laboratory, Division of Biology and Biological Engineering, Beckman Institute, MC 139-74, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125, United States

Funder

Gordon and Betty Moore Foundation

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.6b06823

Reference44 articles.

1. Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

2. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo