Mechanism of the Pseudoirreversible Binding of Amantadine to the M2 Proton Channel

Author:

Llabrés Salomé1,Juárez-Jiménez Jordi1,Masetti Matteo2,Leiva Rosana3,Vázquez Santiago3,Gazzarrini Sabrina4,Moroni Anna4,Cavalli Andrea25,Luque F. Javier1

Affiliation:

1. Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Avgda. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain

2. Department of Pharmacy and Biotecnology (FaBit), Alma Mater Studiorum, University of Bologna, via Belmeloro 6, 40126 Bologna, Italy

3. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain

4. Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan, Via Celoria 26, 20133 Milan, Italy

5. CompuNet, Istituto Italiano di Tecnologia (IIT), via Morego 30, 16163 Genova,Italy

Funder

Ministerio de Ciencia e Innovaci?n

Ministerio de Econom?a y Competitividad

Ministerio de Educaci?n, Cultura y Deporte

Generalitat de Catalunya

Instituci? Catalana de Recerca i Estudis Avan?ats

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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