1. Division of Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada, Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17003, and Departamento Bioquimica y Biologia Molecular, Universidad de La Laguna, Avda Astrofisico Sanchez s/n, 38206, La Laguna, Tenerife, Spain