1. School of Chemistry, Joshep Black Building, King's Buildings, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom, GlaxoSmithKline, Discovery Research, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom, and Evotec Ltd., Milton Park, Abingdon, Oxfordshire OX14 4RZ, United Kingdom