Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate-Reference-Cited by-同舟云学术

Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate

Published:2012-08-30 Issue:17 Volume:55 Page:7472-7479
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Press Neil J.¹,Taylor Roger J.¹,Fullerton Joseph D.,Tranter Pamela¹,McCarthy Clive,Keller Thomas H.,Arnold Nicola,Beer David²,Brown Lyndon,Cheung Robert,Christie Julie,Denholm Alastair,Haberthuer Sandra,Hatto Julia D. I.¹,Keenan Mark,Mercer Mark K.,Oakman Helen¹,Sahri Helene,Tuffnell Andrew R.,Tweed Morris,Tyler John W.¹,Wagner Trixie³,Fozard John R.⁴,Trifilieff Alexandre³

Affiliation:

1. Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

2. Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05-01 Chromos, 138670 Singapore

3. Novartis Institutes for Biomedical Research, Lichtstrasse 35, CH-4056 Basel, Switzerland

4. Novartis Distinguished Scientist, Novartis Institutes for Biomedical Research, Lichtstrasse 35, CH-4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300459a

Reference17 articles.

1. 2 PDE4 Inhibitors – A Review of the Current Field

2. The Potential Role of Phosphodiesterase Inhibitors in the Management of Asthma

3. The Potential of PDE4 Inhibitors in Respiratory Disease

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