Haloemodin as Novel Antibacterial Agent Inhibiting DNA Gyrase and Bacterial Topoisomerase I

Author:

Duan Feixia12,Li Xiaohong3,Cai Suping4,Xin Guang1,Wang Yanyan1,Du Dan1,He Shiliang1,Huang Baozhan1,Guo Xiurong1,Zhao Hang15,Zhang Rui1,Ma Limei1,Liu Yan1,Du Qigen1,Wei Zeliang1,Xing Zhihua1,Liang Yong1,Wu Xiaohua1,Fan Chengzhong6,Ji Chengjie1,Zeng Dequan5,Chen Qianming5,He Yang1,Liu Xuyang4,Huang Wen1

Affiliation:

1. Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University Keyuan 4 Road No. 1, Gaopeng Avenue, Gaoxinqu, Chengdu, Sichuan 610041 China

2. College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, Sichuan 610065, China

3. Department of Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, No. 17, Section 3 Southern Renmin Road, Chengdu 610041, China

4. Shenzhen Eye Hospital, Jinan University, No. 18, Zetian Road, Futian District, Shenzhen 518040, China

5. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University Chengdu, Sichuan 610041, China

6. Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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