1. Division of Analytical Biosciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands, Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, 457 Zhongshan Road, 116023, Dalian, China, SU BioMedicine and TNO Quality of Life, Utrechtseweg 48, P.O. Box 360, 3700 AJ, Zeist, The Netherlands, and Ludwig Institute for Cancer Research, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Oxford OX3 7DQ, United Kingdom