Effects of leonardite and lignite on blood parameters in rats exposed to lead acetate

Author:

Varava M.ORCID

Abstract

The study aimed to research in vivo changes in the hematological and biochemical parameters of laboratory rats' blood when they were continuously exposed to a moderate dose of lead acetate while receiving humic feed additives made of leonardite and lignite. Two-month-old white rats were used to assess the detoxifying properties of the humic compounds leonardite and lignite. The analog pair approach was used to create four groups of eight animals from 32 male laboratory rats for the study. Rats received a pre-meal injection of lead acetate at a dose of 7 mg/100 g of animal weight (1/110 LD50) using a veterinary feeding needle. By creating solutions from lignite and leonardite at a dosage of 18 and 25 mg/kg depending on the active ingredient, humic feed additives were supplied to animals. It has been demonstrated that lignite- and leonardite-based feed additives may affect the morphological parameters of lead acetate-treated rats' blood, including hemoglobin, hematocrit, erythrocyte, and platelet count. These parameters were very near to the levels of the intact rats, which suggests that these humic feed additives may have an anti-anemic impact. The effects of feed additives from leonardite and lignite on laboratory rats in groups that were also exposed to a toxic agent for all 21 days of the experiment led to the normalization of markers of the state of protein metabolism in the group of intact animals (serum protein, albumins, urea, creatinine), particularly activity of the enzyme’s aspartate aminotransferase and alanine aminotransferase. As one of the most crucial indicators of lipid metabolism together with cholesterol, the concentration of triglycerides was slightly lower in the humic substances treated groups than in the intact animals. It was discovered that using a feed supplement made from leonardite in a dosage of 18 mg/kg, which contained more fulvic acids than lignite, led to more favorable blood test results in the research group.

Publisher

Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv

Subject

General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effects of leonardite and succimer treatment on enzyme activity in rats exposed to lead acetate;Ukrainian Journal of Veterinary and Agricultural Sciences;2024-03-19

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3