1. Yingye Zheng is Associate Member, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 . Tianxi Cai is Associate Professor, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115 . Margaret S. Pepe is Member, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 . Wayne C. Levy is Professor, Division of Cardiology, University of Washington, Seattle, WA 98177. This research was supported by National Institutes of Health grants U01-CA86368, P01-CA053996, and R01-GM079330.