Affiliation:
1. Research Institute of Eye Diseases Sciences
Abstract
Neurotrophic keratitis (neurotrophic keratopathy) (NTC) is a degenerative disease of the cornea accompanied with neurogenic inflammation. It is caused by a loss of sensitive innervation of the trigeminal nerve. Therapeutic measures are mainly reduced to maintenance therapy (antiseptics, artificial tears, corneal protectors), which does not affect the cause of the disease. The most affordable and updated therapy is the long-term topical use of auto- or heterologous serum. Recently developed specific approaches to the treatment of NTK — local therapy with recombinant nerve growth factor Cenegermin and corneal neurotization are aimed at the pathogenetic links of the disease and can restore the innervation and sensitivity of the cornea.
Publisher
PE Polunina Elizareta Gennadievna
Reference37 articles.
1. Dua H.S., Said D.G., Messmer E.M., Rolando M., Benitez-Del-Castillo J.M., Hossain P.N., Shortt A.J., Geerling G., Nubile M., Figueiredo F.C., Rauz S., Mastropasqua L., Rama P., Baudouin C. Neurotrophic keratopathy. Prog Retin Eye Res. 2018 Sep;66:107–131. DOI: 10.1016/j.preteyeres.2018.04.003
2. Muller L.J., Marfurt C.F., Kruse F., Tervo T.M. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76(5):521–542. [PubMed] [Google Scholar]
3. Qi H., Chuang E.Y., Yoon K.C., de Paiva C.S., Shine H.D., Jones D.B., Pflugfelder S.C., Li D.Q. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol. Vis. 2007;13:1934–1941.
4. Sigelman S., Friedenwald J.S. Mitotic and wound healing activities of the corneal epithelium: effect of sensory denervation. Arch Ophthalmol. 1954;52:46–57.
5. Mackie I.A. Neuroparalytic keratitis. In: Fraunfelder F., Roy F.H., Meyer S.M., editors. Current Ocular Therapy. Philadelphia, PA, USA: WB Saunders; 1995.