Terms of Use of Perfluoroorganic Compounds for Intraocular Tamponade after Vitrectomy for Rhegmatogenous Retinal Detachment

Abstract

Perfluoroorganic compounds are surgically invasive medical devices, which are represent liquid fluorine-containing substances, chemically and biologically inert and thermodynamically stable due to the strength of chemical bonds between carbon and fluorine atoms. Due to their density, these compounds are able to exert pressure on the detached retina and expel the subretinal fluid. Currently, the use of perfluoroorganic compounds is limited to intraoperative use due to multiplesevere complications of prolonged tamponade. In the analyzed studies, the use of perfluoroorganic compounds as a tamponade was divided into short-term and medium-term tamponade of the vitreal cavity. The authors preferred such tactic for restoring the anatomical fit and a higher rate of aging of retinal laser coagulates, despite proven postoperative complications. Based on the analysis of the results of the presented studies, it can be concluded that it is possible to safely use perfluoroorganic compounds for short-term tamponade of the vitreal cavity. However, among the analyzed domestic and foreign studies, no large-scale statistically significant studies were found to justify the choice of tamponade for retinal breaks different localization, terms of retinal detachment and stage of proliferative vitreoretinopathy. All of that determines the relevance of a more detailed study of the use of perfluoroorganic compounds for short-term tamponade of the vitreal cavity.