Protocol: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review

Abstract

Review question / Objective: In children and youth treated with olanzapine, clozapine, or loxapine and having undergone genotyping, which are the pharmacogenetic variants underlying the antipsychotics' adverse drug reactions and efficacy? What are the most frequently investigated adverse drug reactions and variants ? What is described about the specific effect of CYP1A2 variants ? Therefore, we aimed to review the pharmacogenetic variants underlying olanzapine, clozapine and loxapine ADRs and/or efficacy, in children and youth having undergone genotyping. Then, assessed the most frequently investigated ADRs and genetic polymorphisms in this population. Finally, we investigated the specific effect of CYP1A2 variants in the occurrence of ADRs and/or lack of therapeutic effect. Condition being studied: This review focuses on children, adolescents and youth treated with antipsychotics (olanzapine, clozapine, loxapine) and experienced adverse drug reactions.