Deciphering the Role of Non-Coding RNAs as Regulators in the Wound Healing Process

Abstract

Various factors can influence the complex process of wound healing. Non-coding RNAs (ncRNAs), which include long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), as well as microRNAs (miRNAs), contribute critically to the regulation of wound healing mechanisms. Specific miRNAs regulate fibroblast proliferation, migration, and extracellular matrix production, while others influence keratinocyte migration and re-epithelialization. Some miRNAs also modulate the inflammatory response and regulate angiogenesis during wound healing. The emerging significance of circRNAs in regulating fibroblast and keratinocyte functions during wound healing are also to be noted, as are the significant roles lncRNAs play in influencing various aspects of wound healing. This review underscores the pivotal roles played by ncRNAs in orchestrating the intricate processes involved in wound healing, providing insights into potential therapeutic targets and strategies for enhancing wound healing outcomes.