Biomedical aspects of the use of bacteriocins and glycerolates – possibility of use for the treatment of mastitis in cows

Abstract

Domestic and foreign data on bacteriocin nisin's biomedical and veterinary use are analysed. The mechanism of action of Nisin is based on damage to the structures of the bacterial cell, which leads to the subsequent death of the target cell and makes it possible to reduce the development of microbial resistance. Like most bacteriocins, Nisin has high biological activity due to its effectiveness in the nanomolar range and is a lowtoxic substance. Unlike antibiotics, bacteriocin nisin is completely degraded in the body of humans and animals. An analysis of the sources revealed the safe and effective use of Nisin in clinical practice for treating respiratory, gastrointestinal and skin infections and inflammatory processes in the human oral cavity due to an antimicrobial effect against several microorganisms. It has been established that antimicrobial peptides exhibit synergistic and cytotoxic effects. The effective action of nisin against a wide range of pathogens of animal mastitis has been determined. A study of literary sources on using silicon-boron-containing glycerolates in medical and veterinary practice was carried out. The effective use of glycerolates in treating inflammatory diseases in humans and animals has been established due to their reparative and regenerative effects and high transcutaneous conductivity. The data analysis confirms the feasibility of using bacteriocin nisin with silicon glycerolates and boron bisglycerolates to develop pharmaceutical compositions.