Abstract
Exposure of isolated rat hepatocytes to toxic doses of menadione (2-methyl-1,4- naphthoquinone) results in enhanced formation of active oxygen species, depletion of cellular glutathione and protein thiols, and perturbation of intracellular calcium ion homeostasis. An increase in cytosolic Ca
2+
concentration, resulting from inhibition of the plasma membrane Ca
2+
translocase by menadione metabolism, appears to be critically involved in the development of cytotoxicity.
Subject
Industrial and Manufacturing Engineering,General Agricultural and Biological Sciences,General Business, Management and Accounting,Materials Science (miscellaneous),Business and International Management
Cited by
35 articles.
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