Abstract
Fructose 2,6-bisphosphate has been discovered as a potent stimulator of liver phosphofructokinase. It is also an inhibitor of fructose 1,6-biphosphatase and a stimulator of PP
i
: fructose 6-phosphate phosphotransferase from higher plants. It is formed from fructose 6-phosphate and ATP by a 6-phosphofructo 2-kinase and hydrolysed by a fructose 2,6-bisphosphatase. These two enzymes have very similar physicochemical properties and could not be separated from each other. They are substrates for cyclic-AMP-dependent protein kinase, which inactivates the first enzyme and activates the second.
Subject
Industrial and Manufacturing Engineering,General Agricultural and Biological Sciences,General Business, Management and Accounting,Materials Science (miscellaneous),Business and International Management
Reference15 articles.
1. Mechanism of action of glucagon on hepatocyte phosphofructokinase activity.
2. The regulation of liver pyruvate kinase by phosphorylation-dephosphorylation;Engstrom L.;Regain,1978
3. Gluconeogenesis and related aspects of glycolysis. A;Hers H. G.;Rev. Biochem. (In the press.),1983
4. Fructose 2,6-bisphosphate. Trends biochem;Hers H. G.;Sci.,1982
5. Fructose 2,6-bisphosphate 2 years after its discovery
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献