MIC2: a human pseudoautosomal gene

Abstract

MIC2andXGRare the only known pseudoautosomal genes in man.MIC2encodes the 12E7 antigen, a human cell-surface molecule of unknown function.XGRregulates, incis,the expression of theXGandMIC2genes. DNA probes derived from theMIC2locus have been used in the construction of a meiotic map of the pseudoautosomal region and a long range restriction map into the X- and Y-specific chromosome domains.MIC2is the most proximal marker in the pseudoautosomal region and recombination between the sex chromosomes only rarely includes theMIC2locus. Our long-range restriction maps and chromosome walking experiments have localized the pseudoautosomal boundary within 40 kilobases adjacent to the 3' end of theMIC2gene. The same maps have been used to predict the chromosomal location ofTDF.