Approximate disease dynamics in household-structured populations

Author:

Dodd P.J1,Ferguson N.M1

Affiliation:

1. Department of Infectious Disease Epidemiology, Imperial College LondonSt Mary's Campus, Norfolk Place, London W2 1PG, UK

Abstract

We argue that the large-dimensional dynamical systems which frequently occur in biological models can sometimes be effectively reduced to much smaller ones. We illustrate this by applying projection operator techniques to a mean-field model of an infectious disease spreading through a population of households. In this way, we are able to accurately approximate the dynamics of the system in terms of a few key quantities greatly reducing the number of equations required. We investigate linear stability in this framework and find a new way of calculating the familiar threshold criterion for household systems.

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

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