Advances in understanding bat infection dynamics across biological scales

Author:

Sánchez Cecilia A.1ORCID,Phelps Kendra L.1ORCID,Frank Hannah K.2ORCID,Geldenhuys Marike3ORCID,Griffiths Megan E.4ORCID,Jones Devin N.5ORCID,Kettenburg Gwenddolen6ORCID,Lunn Tamika J.78ORCID,Moreno Kelsey R.9ORCID,Mortlock Marinda3ORCID,Vicente-Santos Amanda10ORCID,Víquez-R Luis R.11ORCID,Kading Rebekah C.12ORCID,Markotter Wanda3ORCID,Reeder DeeAnn M.11ORCID,Olival Kevin J.1ORCID

Affiliation:

1. EcoHealth Alliance, New York, NY 10018, USA

2. Department of Ecology & Evolutionary Biology, Tulane University, New Orleans, LA 70118, USA

3. Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa

4. MRC-University of Glasgow Centre for Virus Research, Glasgow, UK

5. Department of Microbiology & Cell Biology, Montana State University, Bozeman, MT 59717, USA

6. Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA

7. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA

8. Center for the Ecology of Infectious Diseases, University of Georgia, Athens, GA 30602, USA

9. Department of Psychology, Saint Xavier University, Chicago, IL 60655, USA

10. School of Biological Sciences, University of Oklahoma, Norman, OK 73019, USA

11. Department of Biology, Bucknell University, Lewisburg, PA 17837, USA

12. Department of Microbiology, Immunology and Pathology, Center for Vector-borne and Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA

Abstract

Over the past two decades, research on bat-associated microbes such as viruses, bacteria and fungi has dramatically increased. Here, we synthesize themes from a conference symposium focused on advances in the research of bats and their microbes, including physiological, immunological, ecological and epidemiological research that has improved our understanding of bat infection dynamics at multiple biological scales. We first present metrics for measuring individual bat responses to infection and challenges associated with using these metrics. We next discuss infection dynamics within bat populations of the same species, before introducing complexities that arise in multi-species communities of bats, humans and/or livestock. Finally, we outline critical gaps and opportunities for future interdisciplinary work on topics involving bats and their microbes.

Funder

National Research Foundation of South Africa

National Science Foundation

Defense Threat Reduction Agency

Defense Advanced Research Projects Agency

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Medical Research Council

Publisher

The Royal Society

Reference155 articles.

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