COVID-19 vaccine coverage targets to inform reopening plans in a low incidence setting

Author:

Conway Eamon1,Walker Camelia R.2,Baker Christopher234,Lydeamore Michael J.5,Ryan Gerard E.67ORCID,Campbell Trish68,Miller Joel C.9,Rebuli Nic10,Yeung Max11,Kabashima Greg11,Geard Nicholas12ORCID,Wood James10,McCaw James M.26ORCID,McVernon Jodie135,Golding Nick714,Price David J.68ORCID,Shearer Freya M.6ORCID

Affiliation:

1. Population Health and Immunity Division, WEHI, Parkville 3052, Vic, Australia

2. School of Mathematics and Statistics, The University of Melbourne, Melbourne, Victoria, Australia

3. Melbourne Centre for Data Science, The University of Melbourne, Melbourne, Victoria, Australia

4. Centre of Excellence for Biosecurity Risk Analysis, The University of Melbourne, Melbourne, Victoria, Australia

5. Department of Econometrics and Business Statistics, Monash University, Clayton, Victoria, Australia

6. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia

7. Infectious Disease Ecology and Modelling, Telethon Kids Institute, Perth, Western Australia, Australia

8. Department of Infectious Diseases, The University of Melbourne, Melbourne, Victoria, Australia

9. Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia

10. School of Population Health, The University of New South Wales, Sydney, New South Wales, Australia

11. Quantium, Sydney, New South Wales, Australia

12. School of Computing and Information Systems, The University of Melbourne, Melbourne, Victoria, Australia

13. Victorian Infectious Diseases Reference Laboratory Epidemiology Unit at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

14. Curtin School of Population Health, Curtin University, Perth, Western Australia, Australia

Abstract

Since the emergence of SARS-CoV-2 in 2019 through to mid-2021, much of the Australian population lived in a COVID-19-free environment. This followed the broadly successful implementation of a strong suppression strategy, including international border closures. With the availability of COVID-19 vaccines in early 2021, the national government sought to transition from a state of minimal incidence and strong suppression activities to one of high vaccine coverage and reduced restrictions but with still-manageable transmission. This transition is articulated in the national ‘re-opening’ plan released in July 2021. Here, we report on the dynamic modelling study that directly informed policies within the national re-opening plan including the identification of priority age groups for vaccination, target vaccine coverage thresholds and the anticipated requirements for continued public health measures—assuming circulation of the Delta SARS-CoV-2 variant. Our findings demonstrated that adult vaccine coverage needed to be at least 60% to minimize public health and clinical impacts following the establishment of community transmission. They also supported the need for continued application of test–trace–isolate–quarantine and social measures during the vaccine roll-out phase and beyond.

Funder

Australian Government Department of Health Office of Health Protection

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Environmental Science,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference38 articles.

1. Australian Government Department of Health. 2020 Australian Health Protection Principal Committee (AHPPC) statement on strategic direction 24 July 2020 . See https://www.health.gov.au/news/australianhealth-protection-principal-committee-ahppc-statement-on-strategic-direction.

2. COVID-19, Australia: Epidemiology Report 27: fortnightly reporting period ending 11 October 2020;Australian Government Department of Health;Commun. Dis. Intell.,2020

3. COVID-19, Australia: Epidemiology Report 47: reporting period ending 1 August 2021;Australian Government Department of Health;Commun. Dis. Intell.,2021

4. Government of the United Kingdom. 2021 SPI-M-O: Summary of modelling on easing restrictions 3 February 2021 . See https://www.gov.uk/government/publications/spi-m-o-summary-ofmodelling-on-easing-restrictions-3-february-2021.

5. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

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