A non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster exhibits antagonistically pleiotropic fitness effects

Author:

Jardine Michael D.12ORCID,Ruzicka Filip3ORCID,Diffley Charlotte1,Fowler Kevin12ORCID,Reuter Max12ORCID

Affiliation:

1. Department of Genetics, Evolution and Environment, University College London, London, UK

2. Centre for Life's Origins and Evolution, University College London, London, UK

3. School of Biological Sciences and Centre for Geometric Biology, Monash University, Clayton, Australia

Abstract

The amount of genetic variation for fitness within populations tends to exceed that expected under mutation–selection–drift balance. Several mechanisms have been proposed to actively maintain polymorphism and account for this discrepancy, including antagonistic pleiotropy (AP), where allelic variants have opposing effects on different components of fitness. Here, we identify a non-coding indel polymorphism in the fruitless gene of Drosophila melanogaster and measure survival and reproductive components of fitness in males and females of replicate lines carrying each respective allele. Expressing the fruitless region in a hemizygous state reveals a pattern of AP, with one allele generating greater reproductive fitness and the other conferring greater survival to adulthood. Different fitness effects were observed in an alternative genetic background, which may reflect dominance reversal and/or epistasis. Our findings link sequence-level variation at a single locus with complex effects on a range of fitness components, thus helping to explain the maintenance of genetic variation for fitness. Transcription factors, such as fruitless , may be prime candidates for targets of balancing selection since they interact with multiple target loci and their associated phenotypic effects.

Funder

BBSRC

NERC

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Environmental Science,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference47 articles.

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5. Charlesworth B, Hughes KA. 2000 The maintenance of genetic variation in life-history traits. In Evolutionary genetics from molecules to morphology (eds RS Singh, CB Krimbas), pp. 369-392. Cambridge, UK: Cambridge University Press.

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