Affiliation:
1. Department of Entomology and Nematology, Florida Medical Entomology Laboratory, University of FloridaVero Beach, FL 32962, USA
Abstract
Dengue, the most important human arboviral disease, is transmitted primarily by
Aedes aegypti
and, to a lesser extent, by
Aedes albopictus
. The current distributions of these invasive species overlap and are affected by interspecific larval competition in their container habitats. Here we report that competition also enhances dengue infection and dissemination rates in one of these two vector species. We determined the effects of competition on adult
A. aegypti
and
A. albopictus
, comparing their susceptibility to infection with a Southeast Asian strain of dengue-2 virus. High levels of intra- or interspecific competition among larvae enhanced the susceptibility of
A. albopictus
to dengue virus infection and potential for transmission, as indicated by disseminated infections. Doubling the number of competing larvae (
A. albopictus
or
A. aegypti
), led to a significant (more than 60%) increase in the proportion of
A. albopictus
with disseminated dengue-2 infection. Competition-enhanced vector competence appears to result from a reduction in ‘barriers’ (morphological or physiological) to virus infection and dissemination and may contribute to the importance of
A. albopictus
in dengue transmission. Similar results for other unrelated arboviruses suggest that larval competition, common in mosquitoes, should be considered in estimates of vector competence for pathogens that infect humans.
Subject
General Agricultural and Biological Sciences,General Environmental Science,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference66 articles.
1. Modulation of Dengue Virus Infection of Dendritic Cells byAedes aegyptiSaliva
2. Age-dependent bloodfeeding of Aedes aegypti and Aedes albopictus on artificial and living hosts;Alto B.W;J. Am. Mosq. Control Assoc,2003
3. LARVAL COMPETITION DIFFERENTIALLY AFFECTS ARBOVIRUS INFECTION IN AEDES MOSQUITOES
4. Infectious Diseases and Population Cycles of Forest Insects
5. Anderson R.M& May R.M Infectious diseases of humans: dynamics and control. 1991 Oxford UK:Oxford University Press.
Cited by
186 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献