The race between initial T–helper expansion and virus growth upon HIV infection influences polyclonality of the response and viral set

The race between initial T–helper expansion and virus growth upon HIV infection influences polyclonality of the response and viral set–point

Published:2003-07-07 Issue:1522 Volume:270 Page:1349-1358
ISSN:0962-8452
Container-title:Proceedings of the Royal Society of London. Series B: Biological Sciences
language:en
Short-container-title:Proc. R. Soc. Lond. B

Author:

Altes H. Korthals¹,Ribeiro R.M.¹,de Boer R. J.²

Affiliation:

1. Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié–Salpêtrière, 91 Boulevard de l'Hôpital, 75013 Paris, France

2. Theoretical Biology and Bioinformatics Group, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Environmental Science,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2003.2377

Reference48 articles.

1. Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

2. Anderson R. M. & May R. M. 1991 Infectious diseases of humans: dynamics and control. Oxford University Press.

3. Putative Immunodominant Human Immunodeficiency Virus-Specific CD8 + T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

4. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

5. CD40 ligand-mediated interactions are involved in the generation of memory CD8(~) cytotoxic T Iymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection;Borrow P.;J. Virol.,1998

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