Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated

Author:

Kyrchanova Olga12ORCID,Ibragimov Airat23,Postika Nikolay1,Georgiev Pavel1ORCID,Schedl Paul34ORCID

Affiliation:

1. Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia

2. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia

3. Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia

4. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA

Abstract

Expression of Abdominal-B ( Abd-B ) in abdominal segments A5 A8 is controlled by four regulatory domains, iab-5–iab-8 . Each domain has an initiator element (which sets the activity state), elements that maintain this state and tissue-specific enhancers. To ensure their functional autonomy, each domain is bracketed by boundary elements ( Mcp , Fab-7 , Fab-7 and Fab-8 ). In addition to blocking crosstalk between adjacent regulatory domains, the Fab boundaries must also have bypass activity so the relevant regulatory domains can ‘jump over’ intervening boundaries and activate the Abd-B promoter. In the studies reported here we have investigated the parameters governing bypass activity. We find that the bypass elements in the Fab-7 and Fab-8 boundaries must be located in the regulatory domain that is responsible for driving Abd-B expression. We suggest that bypass activity may also be subject to regulation.

Funder

Ministry of Science and Higher Education of the Russian Federation

Russian Science Foundation

National Institutes of Health

Publisher

The Royal Society

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience

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