The multifaceted role of vitamin B 6 in cancer: Drosophila as a model system to investigate DNA damage

Author:

Contestabile Roberto1ORCID,di Salvo Martino Luigi1ORCID,Bunik Victoria234,Tramonti Angela15ORCID,Vernì Fiammetta6ORCID

Affiliation:

1. Istituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’, Sapienza Università di Roma, P.le A. Moro, 5, 00185, Roma, Italy

2. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia

3. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119991, Russia

4. Sechenov Medical University, Sechenov University, 119048 Moscow, Russia

5. Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Pl.e A. Moro, 5, 00185 Roma, Italy

6. Dipartimento di Biologia e Biotecnologie ‘Charles Darwin’, Sapienza Università di Roma, Pl.e A. Moro, 5, 00185 Roma, Italy

Abstract

A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity maintenance and in the establishment of a correct DNA methylation pattern. Failure in the proper accomplishment of these processes accelerates senescence and increases the risk of developing cancer, by promoting the formation of chromosome aberrations and deregulating the expression of oncogenes. Here, the main recent evidence regarding the impact of some B vitamins on DNA damage and cancer is summarized, providing an integrated and updated analysis, mainly centred on vitamin B 6 . In many cases, it is difficult to finely predict the optimal vitamin rate that is able to protect against DNA damage, as this can be influenced by a given individual's genotype. For this purpose, a precious resort is represented by model organisms which allow limitations imposed by more complex systems to be overcome. In this review, we show that Drosophila can be a useful model to deeply understand mechanisms underlying the relationship between vitamin B 6 and genome integrity.

Funder

Russian Foundation for Basic Researches

Consiglio Nazionale delle Ricerche

Sapienza Università di Roma

Istituto Pasteur Italia - Fondazione Cenci Bolognetti

Publisher

The Royal Society

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience

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