Abstract
The discovery of the pronounced anti-rickettsial activity of
p
-sulphonamidobenzamidine on experimental typhus infections in mice has led to a search for compounds of enhanced therapeutic action. A large number of compounds have been prepared in development of the sulphonamido-amidine structure, but anti-rickettsial activity has been found to be confined to about a dozen substances intimately related to
p
-sulphonamidobenzamidine, only one, namely,
p
-sulphonamidobenzamidoxime, having a very slightly superior therapeutic action. The significance of the discovery of yet another sulphonamide type with pronounced biological activity is discussed.
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