Understanding the role of growth factors in embryonic development: insights from the lens-Reference-Cited by-同舟云学术

Understanding the role of growth factors in embryonic development: insights from the lens

Published:2011-04-27 Issue:1568 Volume:366 Page:1204-1218
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Lovicu F. J.¹²³,McAvoy J. W.²³,de Iongh R. U.⁴

Affiliation:

1. Discipline of Anatomy and Histology, Bosch Institute, University of Sydney, NSW 2006, Australia

2. Save Sight Institute, University of Sydney, Sydney, NSW 2001, Australia

3. Vision Cooperative Research Centre, Sydney, Australia

4. Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia

Abstract

Growth factors play key roles in influencing cell fate and behaviour during development. The epithelial cells and fibre cells that arise from the lens vesicle during lens morphogenesis are bathed by aqueous and vitreous, respectively. Vitreous has been shown to generate a high level of fibroblast growth factor (FGF) signalling that is required for secondary lens fibre differentiation. However, studies also show that FGF signalling is not sufficient and roles have been identified for transforming growth factor-β and Wnt/Frizzled families in regulating aspects of fibre differentiation. In the case of the epithelium, key roles for Wnt/β-catenin and Notch signalling have been demonstrated in embryonic development, but it is not known if other factors are required for its formation and maintenance. This review provides an overview of current knowledge about growth factor regulation of differentiation and maintenance of lens cells. It also highlights areas that warrant future study.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2010.0339

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