The BRAIN Initiative: developing technology to catalyse neuroscience discovery

Author:

Jorgenson Lyric A.1,Newsome William T.2,Anderson David J.3,Bargmann Cornelia I.4,Brown Emery N.56,Deisseroth Karl7,Donoghue John P.8,Hudson Kathy L.1,Ling Geoffrey S. F.9,MacLeish Peter R.10,Marder Eve11,Normann Richard A.12,Sanes Joshua R.13,Schnitzer Mark J.14,Sejnowski Terrence J.15,Tank David W.16,Tsien Roger Y.17,Ugurbil Kamil18,Wingfield John C.19

Affiliation:

1. Office of the Director, National Institutes of Health, Bethesda, MD 20892, USA

2. Howard Hughes Medical Institute and Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA

3. Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA

4. Howard Hughes Medical Institute and Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA

5. Institute for Medical Engineering and Science and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

6. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA

7. Howard Hughes Medical Institute and Department of Bioengineering, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA

8. Brown Institute for Brain Science, Brown University, Providence, RI 02912, USA

9. Biological Technologies Office, Defense Advanced Research Projects Agency, Arlington, VA 22203, USA

10. Department of Neurobiology, Neuroscience Institute, Morehouse, School of Medicine, Atlanta, GA 30310, USA

11. Biology Department and Volen Center, Brandeis University, Waltham, MA 02454, USA

12. Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA

13. Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA

14. Howard Hughes Medical Institute and James H. Clark Center for Biomedical Engineering & Sciences, CNC Program, Stanford University, Stanford, CA 94305, USA

15. Howard Hughes Medical Institute and Computational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA

16. Princeton Neuroscience Institute, Bezos Center for Neural Circuit Dynamics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA

17. Howard Hughes Medical Institute and Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA

18. Center for Magnetic Resonance Research, University of Minnesota, MN 55454, USA

19. Directorate for Biological Sciences, National Science Foundation, Arlington, VA 22230, USA

Abstract

The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. Capitalizing on this momentum, the United States launched the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to develop and apply new tools and technologies for revolutionizing our understanding of the brain. In this article, we review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research. Particular emphasis is given to its potential impact on the mapping and study of neural circuits, and how this knowledge will transform our understanding of the complexity of the human brain and its diverse array of behaviours, perceptions, thoughts and emotions.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference82 articles.

1. President Obama. 2013 Remarks by the President on the BRAIN Initiative and American Innovation. See http://www.whitehouse.gov/the-press-office/2013/04/02/remarks-president-brain-initiative-and-american-innovation.

2. NIH Advisory Committee. 2013 Charge to the NIH BRAIN Working Group. See http://www.braininitiative.nih.gov/acd-charge.pdf.

3. Advisory Committee to the NIH Director. 2013 NIH BRAIN Working Group Interim Report. See http://www.braininitiative.nih.gov/11252013-Interim-Report-Final.pdf.

4. BRAIN Working Group. 2014 BRAIN 2025: a scientific vision—NIH BRAIN Working Group Final Report. See http://www.braininitiative.nih.gov/2025/index.htm.

5. Developmental genetics of vertebrate glial–cell specification

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