Biological challenges to effective vaccines in the developing world-Reference-Cited by-同舟云学术

Biological challenges to effective vaccines in the developing world

Published:2015-06-19 Issue:1671 Volume:370 Page:20140138
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Grassly Nicholas C.¹²,Kang Gagandeep²,Kampmann Beate³⁴

Affiliation:

1. Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Hospital, Norfolk Place, London W2 1PG, UK

2. The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India

3. Department of Medicine, Imperial College London, St Mary's Hospital, Norfolk Place, London W2 1PG, UK

4. Vaccinology Theme, MRC Unit, The Gambia, Atlantic Road, Fajara, The Gambia

Abstract

The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2014.0138

Reference47 articles.

1. Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

2. Diphtheria toxoid

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