Affiliation:
1. The Francis Crick Institute, London NW1 1AT, UK
Abstract
Time is inherent to biological processes. It determines the order of events and the speed at which they take place. However, we still need to refine approaches to measure the course of time in biological systems and understand what controls the pace of development. Here, we argue that the comparison of biological processes across species provides molecular insight into the timekeeping mechanisms in biology. We discuss recent findings and the open questions in the field and highlight the use ofin vitrosystems as tools to investigate cell-autonomous control as well as the coordination of temporal mechanisms within tissues. Further, we discuss the relevance of studying tempo for tissue transplantation, homeostasis and lifespan.
Funder
European Molecular Biology Organization
Wellcome Trust
Francis Crick Institute
Subject
Biomedical Engineering,Biomaterials,Biochemistry,Bioengineering,Biophysics,Biotechnology
Cited by
18 articles.
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