Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in <i>Drosophila</i>-Reference-Cited by-同舟云学术

Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila

Published:2022-03 Issue:3 Volume:12 Page:
ISSN:2046-2441
Container-title:Open Biology
language:en
Short-container-title:Open Biol.

Author:

Ding Xiang¹,Li Zhuojie¹,Peng Kai¹,Zou Rui¹,Wu Chenxi¹²,Lin Gufa³^ORCID,Li Wenzhe¹,Xue Lei¹⁴⁵^ORCID

Affiliation:

1. Institute of Intervention Vessel, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, People's Republic of China

2. College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei, People's Republic of China

3. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People's Republic of China

4. Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong, People's Republic of China

5. National Clinical Research Center for Interventional Medicine, Shanghai 10th People's Hospital, Tongji University, Shanghai, People's Republic of China

Abstract

Snail (Sna) plays a pivotal role in epithelia-mesenchymal transition and cancer metastasis, yet its functions in normal tissue development remain elusive. Here, using Drosophila as a model organism, we identified Sna as an essential regulator of Hippo signalling-mediated cell proliferation and tissue growth. First, Sna is necessary and sufficient for impaired Hippo signalling-induced cell proliferation and tissue overgrowth. Second, Sna is necessary and sufficient for the expression of Hippo pathway target genes. Third, genetic epistasis data indicate Sna acts downstream of Yki in the Hippo signalling. Finally, Sna is physiologically required for tissue growth in normal development. Mechanistically, Yki activates the transcription of sna , whose protein product binds to Scalloped (Sd) and promotes Sd-dependent cell proliferation. Thus, this study uncovered a previously unknown physiological function of Sna in normal tissue development and revealed the underlying mechanism by which Sna modulates Hippo signalling-mediated cell proliferation and tissue growth.

Funder

Shanghai Committee of Science and Technology

National Natural Science Foundation of China

Research Funds for the Central Universities

Publisher

The Royal Society

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.210357

Reference51 articles.

1. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis