Bone tissue reactions to biomimetic ion-substituted apatite surfaces on titanium implants

Author:

Ballo Ahmed M.12,Xia Wei23,Palmquist Anders12,Lindahl Carl23,Emanuelsson Lena12,Lausmaa Jukka24,Engqvist Håkan23,Thomsen Peter12

Affiliation:

1. Department of Biomaterials, Institute for Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

2. BIOMATCELL, VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden

3. Angstrom Laboratory, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden

4. Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås, Sweden

Abstract

The aim of this study was to evaluate the bone tissue response to strontium- and silicon-substituted apatite (Sr-HA and Si-HA) modified titanium (Ti) implants. Sr-HA, Si-HA and HA were grown on thermally oxidized Ti implants by a biomimetic process. Oxidized implants were used as controls. Surface properties, i.e. chemical composition, surface thickness, morphology/pore characteristics, crystal structure and roughness, were characterized with various analytical techniques. The implants were inserted in rat tibiae and block biopsies were prepared for histology, histomorphometry and scanning electron microscopy analysis. Histologically, new bone formed on all implant surfaces. The bone was deposited directly onto the Sr-HA and Si-HA implants without any intervening soft tissue. The statistical analysis showed significant higher amount of bone–implant contact (BIC) for the Si-doped HA modification ( P = 0.030), whereas significant higher bone area (BA) for the Sr-doped HA modification ( P = 0.034), when compared with the non-doped HA modification. The differences were most pronounced at the early time point. The healing time had a significant impact for both BA and BIC ( P < 0.001). The present results show that biomimetically prepared Si-HA and Sr-HA on Ti implants provided bioactivity and promoted early bone formation.

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

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