Natural polymers for the microencapsulation of cells

Author:

Gasperini Luca12ORCID,Mano João F.12,Reis Rui L.12

Affiliation:

1. 3B's, Department of Polymer Engineering, University of Minho, 4806-909 Caldas das Taipas, Portugal

2. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal

Abstract

The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an attractive procedure for many biomedical and biotechnological applications, such as xenotransplantation, maintenance of stem cell phenotype and bioprinting of three-dimensional scaffolds for tissue engineering and regenerative medicine. In this review, we focus on naturally derived polymers that can form hydrogels under mild conditions and that are thus capable of entrapping cells within controlled volumes. Our emphasis will be on polysaccharides and proteins, including agarose, alginate, carrageenan, chitosan, gellan gum, hyaluronic acid, collagen, elastin, gelatin, fibrin and silk fibroin. We also discuss the technologies commonly employed to encapsulate cells in these hydrogels, with particular attention on microencapsulation.

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

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