Hyperpolarized 83 Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Author:

Lilburn David M. L.1,Lesbats Clémentine1,Six Joseph S.1,Dubuis Eric2,Yew-Booth Liang2,Shaw Dominick E.3,Belvisi Maria G.2,Birrell Mark A.2,Pavlovskaya Galina E.1,Meersmann Thomas1

Affiliation:

1. Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK

2. Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK

3. City Hospital Nottingham, Nottingham Respiratory Research Unit, Nottingham NG5 1PB, UK

Abstract

Hyperpolarized 83 Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope 83 Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant 83 Kr T 1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83 Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

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