Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine-Reference-Cited by-同舟云学术

Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine

Published:2012-05-23 Issue:73 Volume:9 Page:1713-1724
ISSN:1742-5689
Container-title:Journal of The Royal Society Interface
language:en
Short-container-title:J. R. Soc. Interface.

Author:

McNamara Laura E.¹,Sjöström Terje²,Meek R. M. Dominic³,Oreffo Richard O. C.⁴,Su Bo²,Dalby Matthew J.¹,Burgess Karl E. V.⁵

Affiliation:

1. The Centre for Cell Engineering, Division of Molecular, Cell, and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

2. School of Oral and Dental Science, University of Bristol, Bristol, UK

3. Department of Orthopaedic and Trauma Surgery, Southern General Hospital, Glasgow, UK

4. Bone and Joint Research Group, Human Development and Health, Institute of Developmental Science, University of Southampton Medical School, Southampton, UK

5. Sir Henry Wellcome Functional Genomics Facility, Division of Integrative and Systems Biology, University of Glasgow, Glasgow, UK

Abstract

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2012.0169

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