Affiliation:
1. School of Food Science, Washington State University, Pullman, WA 99164, USA
2. School of Food Science, University of Idaho, Moscow, ID 83844, USA
Abstract
Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions. This review summarizes the favourable outcomes of AMPK activation on intestinal health, and discusses AMPK as a potential therapeutic target for intestinal diseases.
Funder
National Institute for Health Research
Washington State University Agricultural Research Center Emerging Research Issues Internal Competitive Grant
Subject
General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience
Cited by
47 articles.
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