Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different-Reference-Cited by-同舟云学术

Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different

Published:2018-11 Issue:11 Volume:8 Page:180157
ISSN:2046-2441
Container-title:Open Biology
language:en
Short-container-title:Open Biol.

Author:

Su Tin Tin¹²^ORCID

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA

2. University of Colorado Comprehensive Cancer Center, Anschutz Medical Campus, 13001 E. 17th Pl., Aurora, CO 80045, USA

Abstract

The ability to regenerate is a fundamental requirement for tissue homeostasis. Regeneration draws on three sources of cells. First and best-studied are dedicated stem/progenitor cells. Second, existing cells may proliferate to compensate for the lost cells of the same type. Third, a different cell type may change fate to compensate for the lost cells. This review focuses on regeneration of the third type and will discuss the contributions by post-transcriptional mechanisms including the emerging evidence for cell-autonomous and non-lethal roles of cell death pathways.

Funder

National Institute of General Medical Sciences

Publisher

The Royal Society

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180157

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