Conjugation is necessary for a bacterial plasmid to survive under protozoan predation

Author:

Cairns Johannes1,Jalasvuori Matti2,Ojala Ville2,Brockhurst Michael3,Hiltunen Teppo1ORCID

Affiliation:

1. Department of Food and Environmental Sciences/Microbiology and Biotechnology, University of Helsinki, PO Box 65, Helsinki 00014, Finland

2. Department of Biological and Environmental Science/Centre of Excellence in Biological Interactions, University of Jyväskylä, PO Box 35, Jyväskylä 40014, Finland

3. Department of Biology, University of York, York YO10 5DD, UK

Abstract

Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogen Serratia marcescens . A conjugation-defective mutant plasmid was unable to survive under predation, suggesting that conjugative transfer is required for plasmid persistence under the realistic condition of predation. These results indicate that multi-trophic interactions can affect the maintenance of conjugative plasmids with implications for bacterial evolution and the spread of antibiotic resistance genes.

Funder

Suomen Akatemia

Helsingin Yliopisto

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,Agricultural and Biological Sciences (miscellaneous)

Reference20 articles.

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4. The evolution of a conjugative plasmid and its ability to increase bacterial fitness;Dionisio F;Biol,2005

5. Natural selection, infectious transfer and the existence conditions for bacterial plasmids;Bergstrom CT;Genetics,2000

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