Chronic stress elevates telomerase activity in rats-Reference-Cited by-同舟云学术

Chronic stress elevates telomerase activity in rats

Published:2012-10-10 Issue:6 Volume:8 Page:1063-1066
ISSN:1744-9561
Container-title:Biology Letters
language:en
Short-container-title:Biol. Lett.

Author:

Beery Annaliese K.¹,Lin Jue²,Biddle Joshua S.³,Francis Darlene D.³,Blackburn Elizabeth H.²,Epel Elissa S.⁴

Affiliation:

1. Robert Wood Johnson Health & Society Scholar at University of California at San Francisco, San Francisco, CA 04143 and University of California at Berkeley, CA 94720, USA

2. Departments of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158-2517, USA

3. Departments of Public Health and Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720-1650, USA

4. Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143, USA

Abstract

The enzyme telomerase lengthens telomeres—protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related physiological and behavioural outcomes. This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,Agricultural and Biological Sciences (miscellaneous)

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsbl.2012.0747

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