Approaches to natural-product synthesis with organometallic systems based on iron, molybdenum and manganese

Author:

Abstract

New methods for the construction of quaternary carbon centres, with organoiron and organomolybdenum chemistry, are presented. Regiocontrolled addition of tin enolates to substituted cyclohexadienyliron tricarbonyl complexes leads to a new approach to trichothecene synthesis, illustrated by a short total synthesis of ( + )- trichodiene. A new coupling reaction of alkenes and diene-Fe(CO) 3 units is described, the outcome of which is equivalent to a [6 + 2] ene reaction. Some applications of arene-manganese tricarbonyl complexes to the preparation of substituted diaryl ethers are discussed, in the context of synthetic approaches to the glycopeptide antibiotics ristocetin A and vancomycin. Finally, stereocontrolled nucleophilic addition to cycloheptadienyliron complexes is illustrated and applied to a synthesis of the Prelog-Djerassi lactone.

Publisher

The Royal Society

Subject

General Engineering

Reference27 articles.

1. Bamburg J. R. & Strong F. M. 1971 In Microbiol toxins (eds. S. Kadis A. Ciegler & S. J. Ajl) vol. 7 pp 107-292 New York: Academic Press.

2. Organometallic complexes in synthesis. Part V. Some tricarbonyliron derivatives of cyclohexadienecarboxylic acids

3. Birch A. J. Narula A. S. Dahler P. Stephenson G. R. & Kelly L. F. 1980 Tetrahedron Lett. 21 979.

4. Birch A. J. Raverty W. D. & Stephenson G. R. 1984 Organometallics 3 1075.

5. Bond A. Lewis B. & Green M. 1975 J.chem. Soc. Dalton Trans. pp. 1137.

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