Aquaporin–graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

Author:

Jakowiecki Jakub1ORCID,Sztyler Agnieszka1,Filipek Slawomir1,Li Pingzuo2,Raman Karthik3,Barathiraja Natarajan4,Ramakrishna Seeram5,Eswara Jairam R.6,Altaee Ali7,Sharif Adel O.8,Ajayan Pulickel M.9,Renugopalakrishnan Venkatesan1011

Affiliation:

1. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

2. Shanghai Research Center of Biotechnology, Chinese Academy of Sciences, Shanghai 200233, People's Republic of China

3. EREOI Power Solutions Pvt Ltd, no. 9, Nagarbhavi 1st Stage, 3rd Block, 1st Main Road, BDA Layout, Pattegarapalya Main Road, Bangalore 560079, India

4. Aquablue LLC, 56B High Street, Milford, MA 01757, USA

5. Nanoscience and Nanotechnology Initiative, National University of Singapore, Engineering Drive 3, 117576 Singapore, Republic of Singapore

6. Division of Urology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA

7. School of Civil and Environmental Engineering, University of Technology, Sydney, New South Wales 2007, Australia

8. Center for Osmosis Research and Applications, Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK

9. Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA

10. Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA

11. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA

Abstract

The aquaporin superfamily of hydrophobic integral membrane proteins constitutes water channels essential to the movement of water across the cell membrane, maintaining homeostatic equilibrium. During the passage of water between the extracellular and intracellular sides of the cell, aquaporins act as ultra-sensitive filters. Owing to their hydrophobic nature, aquaporins self-assemble in phospholipids. If a proper choice of lipids is made then the aquaporin biomimetic membrane can be used in the design of an artificial kidney. In combination with graphene, the aquaporin biomimetic membrane finds practical application in desalination and water recycling using mostly Escherichia coli AqpZ. Recently, human aquaporin 1 has emerged as an important biomarker in renal cell carcinoma. At present, the ultra-sensitive sensing of renal cell carcinoma is cumbersome. Hence, we discuss the use of epitopes from monoclonal antibodies as a probe for a point-of-care device for sensing renal cell carcinoma. This device works by immobilizing the antibody on the surface of a single-layer graphene, that is, as a microfluidic device for sensing renal cell carcinoma.

Funder

Rothschild Foundation, NIH, NSF, USAFOSR and the Wallace H. Coulter Foundation

Publisher

The Royal Society

Subject

Biomedical Engineering,Biomaterials,Biochemistry,Bioengineering,Biophysics,Biotechnology

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3