Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer-Reference-Cited by-同舟云学术

Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer

Published:2019-02-15 Issue:2 Volume:9 Page:20180077
ISSN:2042-8898
Container-title:Interface Focus
language:en
Short-container-title:Interface Focus.

Author:

Tkac Jan¹²^ORCID,Gajdosova Veronika¹,Hroncekova Stefania¹,Bertok Tomas¹²,Hires Michal¹,Jane Eduard¹,Lorencova Lenka¹²,Kasak Peter³

Affiliation:

1. Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 84538 Bratislava, Slovakia

2. Glycanostics Ltd, Dubravska cesta 9, 84538 Bratislava, Slovakia

3. Center for Advanced Materials, Qatar University, Doha 2713, Qatar

Abstract

The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, outperforming traditional PSA tests. The review provides a detailed and comprehensive summary that PSA glycoprofiling can effectively solve this problem, thereby considerably reducing the number of unnecessary biopsies. In addition, PSA glycoprofiling can serve as a prognostic PCa biomarker to identify PCa patients with an aggressive form of PCa, avoiding unnecessary further treatments which are significantly life altering (incontinence or impotence).

Funder

H2020 European Research Council

Agentúra Ministerstva školstva, vedy, výskumu a športu SR

Agentúra na Podporu Výskumu a Vývoja

Horizon 2020 Framework Programme

European Regional Development Fund

Publisher

The Royal Society

Subject

Biomedical Engineering,Biomaterials,Biochemistry,Bioengineering,Biophysics,Biotechnology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsfs.2018.0077

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